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| RHP Tim Adleman (El Paso/Lincoln 2012) Cincinnati 2016-17 |
RHP John Brebbia (Sioux Falls 2014, Laredo 2015) St. Louis 2017-20 San Francisco 2021- |
RHP Angel Castro (Lincoln 2010) Oakland 2015 |
INF Ryan Court (Sioux City 2015) Seattle 2019 |
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| RHP Aaron Crow (Fort Worth 2008-09) Kansas City 2011-2014 |
RHP Dane De La Rosa (El Paso 2009) Tampa Bay 2011-12 L.A. Angels 2013-14 |
OF Johnny Davis (Kansas City 2018) Tampa Bay 2019 |
RHP Brett Eibner (Texas 2019) Miami 2020 |
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| OF Joey Gathright (Shreveport 2011) Boston 2011 |
RHP Junior Guerra (Wichita 2011, 2013) Chicago White Sox 2015 Milwaukee 2016-19 Arizona 2020 Los Angeles Angels 2021- |
RHP Luke Hochevar (Fort Worth 2006) Kansas City 2007-16 |
RHP John Holdzkom (Sioux City 2013, Amarillo 2013-14) Pittsburgh 2014 |
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| RHP James Hoyt (Wichita 2012) Houston 2016-18 Cleveland 2019 Miami 2020 |
RHP Chris Jakubauskas (Lincoln 2007) Seattle 2009 Pittsburgh 2010 Baltimore 2011 |
LHP Kris Johnson (Kansas City 2011) Pittsburgh 2013 Minnesota 2014 |
LHP Mike Kickham (Kansas City 2016) Boston 2020 |
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| RHP Brandon Kintzler (St. Paul 2009) Milwaukee 2010-15 Minnesota 2016-17 Washington 2017-18 Chicago Cubs 2018-19 Miami 2020 Philadelphia 2021- |
LHP Brandon Mann (Fargo-Moorhead 2015) Texas 2018 |
RHP Parker Markel (Sioux City 2018) Seattle 2019 Pittsburgh 2019 |
RHP Chris Martin (Grand Prairie 2010) Colorado 2014 New York Yankees 2015 Texas 2018-19 Atlanta 2019- |
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| LHP Tyler Matzek (Texas 2018-19) Atlanta 2020- |
1B John Nogowski (Sioux City 2017) St. Louis 2020- |
LHP James Paxton (Grand Prairie 2010) Seattle 2013-18, 2021- New York Yankees 2019-20 |
OF David Peralta (Wichita 2012, Amarillo 2013) Arizona 2014- |
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| C Eddy Rodriguez (El Paso 2009, Sioux Falls 2010) San Diego 2012 |
RHP Chaz Roe (Laredo 2012) Arizona 2013 New York Yankees 2014 Baltimore 2015-16 Atlanta 2016-17 Tampa Bay 2017- |
RHP Tanner Scheppers (St. Paul 2009) Texas 2012-17 |
RHP Max Scherzer (Fort Worth 2006) Arizona 2008-09 Detroit 2010-2014 Washington 2015- |
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| RHP Bo Schultz (Grand Prairie 2011) Arizona 2014 Toronto 2015-16 |
RHP Tayler Scott (Sioux City 2016) Seattle 2019 Baltimore 2019 |
RHP Chris Smith (Wichita 2013) Oakland 2016-17 |
LHP Caleb Thielbar (St. Paul 2011, 2016-17) Minnesota 2013-15, 2020- |
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| LHP Ian Thomas (Winnipeg 2011) Atlanta 2014-15 L.A. Dodgers 2015 |
RHP Aaron Wilkerson (Grand Prairie 2013-14) Milwaukee 2017-19 |
