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| RHP John Brebbia (Sioux Falls 2014, Laredo 2015) San Francisco Giants |
RHP Junior Guerra (Wichita 2011, 2013) Arizona Diamondbacks |
RHP James Hoyt (Wichita 2012) Miami Marlins |
LHP Mike Kickham (Kansas City 2016) Boston Red Sox |
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| RHP Brandon Kintzler (St. Paul 2009) Miami Marlins |
RHP Chris Martin (Grand Prairie 2010) Atlanta Braves |
LHP Tyler Matzek (Texas 2018-19) Atlanta Braves |
LHP James Paxton (Grand Prairie 2010) New York Yankees |
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| OF David Peralta (Wichita 2012, Amarillo 2013) Arizona Diamondbacks |
RHP Chaz Roe (Laredo 2012) Tampa Bay Rays |
RHP Max Scherzer (Fort Worth 2007) Washington Nationals |
LHP Caleb Thielbar (St. Paul 2011, 2016-17) Minnesota Twins |
Currently in foreign major leagues
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| LHP Kris Johnson (Kansas City 2011) Hiroshima Carp (Japan) |
RHP Tayler Scott (Sioux City 2016) Hiroshima Carp (Japan) |
